Platform
Four stages, one open pipeline
EnzymeBase organizes its work into four stages: identifying a disease-relevant enzyme target, computing a candidate inhibitor, validating it in a biological system, and publishing the result as a citable record other researchers can build on.
01 · Target & Inhibitor Discovery
Naming the target
Curated profiles of disease-relevant enzyme targets, currently BACE1 and AChE, paired with candidate natural inhibitors from Indonesian flora, linked to source species and reported activity.
02 · Enzyme Informatics
Computing the fit
Computational screening of candidates against target structures via molecular docking, with molecular dynamics simulation to assess binding stability over time. See Methods for how each is applied.
03 · Mechanistic Validation
Testing it in a system
In-silico predictions are followed into a biological system: histology and gene expression validation (qRT-PCR) of target and co-target genes in established disease models. See Methods for how each is applied.
04 · Open Reference & Translation
Making it citable
Validated entries are published as an open, citable reference, so a thesis or study’s findings remain usable by other researchers working on the same targets or source species.